Jose Trevino blasted a three-run homer and Luis Severino allowed one run on one hit over six innings to lead the New York Yankees to a 6-2 victory over the host Baltimore Orioles to open a four-game series on Monday.

After the Yankees took a 1-0 lead on Giancarlo Stanton’s double that scored Anthony Rizzo in the third inning, Trevino provided the big blow an inning later.

Gleyber Torres singled to left to open the fourth. Joey Gallo then struck out before Torres took second on Isiah Kiner-Falefa’s infield single to shortstop.

Two pitches later, Trevino drilled rookie right-hander Kyle Bradish’s fastball off the right-field foul pole to clear the bases and extend the lead to 4-0.

The Orioles pulled to within 4-1 on the first of Anthony Santander’s two solo home runs, as he hit one to right field as a left-handed hitter in the fourth before clearing the left-field fence as a right-handed hitter in the ninth.

The Orioles’ other hit was a single by Rougned Odor in the seventh inning.

Josh Donaldson and Rizzo hit back-to-back solo homers in the ninth inning.

Severino (3-0) had seven strikeouts against just two walks to beat the Orioles for the second time this season. He allowed four earned runs on three hits to go along with five strikeouts and two walks in six innings, picking up the win in the Yankees’ 12-8 victory on April 26.

Right-hander Jonathan Loaisiga held the Orioles scoreless in the seventh and Chad Green took care of the eighth before turning it over to Aroldis Chapman, who closed it out in the ninth.

Bradish, making just the fourth start of his career, dropped to 1-2 after allowing four earned runs on eight hits with six strikeouts and three walks in 4 1/3 innings before being relieved by Keegan Akin.

Akin allowed just one hit to go along with three strikeouts and a walk over 3 2/3 innings.

Donaldson had a game-high three hits, while Torres had two hits and two walks and Trevino had two hits for the Yankees.

–Field Level Media

Sandy Alcantara retired the final 20 batters he faced, leading the host Miami Marlins to an 8-2 win over the Washington Nationals on Monday night.

With his start moved up due to Jesus Luzardo being placed on the injured list on Sunday, Alcantara allowed just three hits, one walk and one run in eight innings, striking out four.

Alcantara (3-2) struggled early, requiring 43 pitches to complete two innings. But he needed just 57 pitches over the next six frames.

The Marlins trailed early on Monday but had a four-run second inning, led by Avisail Garcia’s solo home run.

Miami finished with a season-high 16 hits, including three each by Jazz Chisholm Jr. and Bryan De La Cruz. All three of Chisholm’s hits were over 100 mph in exit velocity.

Garcia, Jorge Soler and Erik Gonzalez each had two RBIs for Miami.

Washington starter Aaron Sanchez (2-3) took the loss, allowing eight hits, three walks and four runs.

Miami allowed a first-inning run for the fourth straight game as three of Washington’s first four hitters singled. Cesar Hernandez got an infield knock, Josh Bell grounded a single just under the glove of Chisholm at second base and Yadiel Hernandez earned the RBI with a liner that deflected off shortstop Gonzalez’s mitt.

Alcantara escaped further trouble when Maikel Franco bounced into a bases-loaded force out at the plate and Lane Thomas struck out looking.

Garcia’s 402-foot homer got the Marlins going in the second, tying the score 1-1. Then, after Brian Anderson walked and De La Cruz doubled, Gonzalez smacked a two-run single. Jacob Stallings followed with a double, and Chisholm capped the rally with an RBI single for a 4-1 lead.

The Marlins loaded the bases with no outs in the seventh. Soler then smashed a ball 117 mph to shortstop Dee Strange-Gordon, who couldn’t handle it as two runs scored on the single. A third run scored on the play as pitcher Victor Arano, backing up home plate, tried to cut down Soler at second.

Garcia capped the rally with an RBI single, giving Miami an 8-1 lead.

Washington closed the scoring with Thomas’ RBI single in the ninth off reliever Anthony Bass.

–Field Level Media

Harold Castro hit a tiebreaking, two-out homer in the ninth inning as the Detroit Tigers won their fourth straight game by edging the Tampa Bay Rays 3-2 Monday night in St. Petersburg, Fla.

With the game tied at 2, Castro lifted an 0-1 fastball from Andrew Kittredge (3-1) deep to right-center for his first homer and the game-winning blow, making a winner of reliever Michael Fulmer (2-2).

Closer Gregory Soto allowed a single but retired Mike Zunino with a flyout to center field to shut down the Rays in the ninth for his sixth save in seven chances.

Jonathan Schoop swatted a two-run homer, and Willi Castro went 2-for-4. Miguel Cabrera collected a single to stretch his hitting streak to seven games.

A native of Tampa, Detroit starter Alex Faedo was strong over 5 2/3 innings in his third career start and first-ever in a big-league uniform in front of his family and friends. He allowed one run and four hits in the outing, striking out four and walking one in his 83-pitch effort.

For the Rays, Brett Phillips had a big night at the plate by going 3-for-3 with a homer, double, two runs scored and an RBI.

In his seventh start, Tampa Bay’s Corey Kluber yielded two runs and four hits in six innings. He struck out a season-high eight and didn’t issue a walk.

After Cabrera’s leadoff single in the fourth, Schoop barreled up an 88 mph sinker from Kluber that ran inside on the right-handed hitter. The long homer to left field, an estimated 404 feet, was Schoop’s third this season.

Leading off the sixth, Phillips launched a towering shot off Faedo’s 91 mph four-seam fastball, a majestic blast down the right-field line that caromed off the C-ring near the roof of the domed stadium. The ball bounced back into right field as the fleet Phillips sped around the bases.

Detroit manager A.J. Hinch challenged the play, but the home-run call was upheld for Phillips’ third long ball.

Phillips legged out a hustle double in the eighth with Detroit playing its outfield deep, and a walk to Yandy Diaz and a wild pitch led to Wander Franco’s tying sacrifice fly.

–Field Level Media