Novak Djokovic said he was pain-free in dismantling Alex de Minaur to reach the quarterfinals of the Australian Open, which serves as a major red flag for the seven other remaining players in the men’s singles draw in Melbourne.

Djokovic had been concerned about his ability to complete the two-week tournament due to a left hamstring injury, but said he felt “fantastic” while dispatching de Minaur 6-1, 6-1, 6-2 to reach the quarters in Australia for the 13th time.

Djokovic, the No. 4 seed, is now the -200 favorite by BetMGM to win his 10th Australian Open and tie Rafael Nadal for the most all-time Grand Slam titles with 22.

“The way my leg felt before tonight wasn’t giving me too many hopes, so to say, for the entire tournament, to go all the way through,” he said after the match. “Tonight I feel that, so I feel positive about it.”

Djokovic will next face Russia’s Andrey Rublev, who only survived a fifth-set tiebreaker against Holger Rune courtesy of a net cord on match point.

“No one wants to face Novak. I’d rather be in any other part of the draw,” Rublev said after the match.

Oddsmakers feel the same way, as Rublev holds the fifth-longest odds to win the men’s title at +1600 despite being one of three top-five seeds remaining. No. 3 seed Stefanos Tsitsipas, who survived his one five-set marathon in the fourth round, is second to Djokovic at +350, and will next play unseeded Jiri Lehecka (+4000).

There are three Americans remaining among the final eight in Melbourne for the first time since 2000. No. 29 seed Sebastian Korda (+900) will take on 18th-seeded Karen Khachanov.

At least one American man will reach the semifinals. Tommy Paul (+2200) will battle Brian Shelton (+5000), who rallied to win the final two sets against countryman J.J. Wolf in the fourth round. Paul and the 20-year-old Shelton will be playing in their first career Grand Slam quarterfinals.

In the women’s draw, Aryna Sabalenka enters the quarterfinals as the +225 favorite. The fifth-seeded Belarusian has not dropped a set while taking out a pair of ranked players en route to the quarters.

Sabalenka is favored over No. 3 seed Jessica Pegula and No. 22 Elena Rybakina, who are both being offered at +325.

Pegula faces a tough quarterfinal match against No. 24 Victoria Azarenka (+1200), whose previous two major titles both came at the Australian Open (2012-13).

“I feel more confident,” Pegula said after her fourth-round match. “I feel more experienced being in this position. I feel a little more settled than I have in the past.”

Rybakina will take on hard-hitting Jelena Ostapenko (+1200), who dispatched American Coco Gauff in straight sets to become the first Latvian woman to reach the quarters of the Australian Open.

The women’s draw has been marked by big upsets.

After Pegula and Sabalenka, the highest-ranked remaining player is Ostapenko at No. 17.

Top-seeded Iga Swiatek was upset in the fourth round, while No. 2 Ons Jabeur failed to make it out of the second. No. 4 seed Caroline Garcia continued the upset trend when she fell to Magda Linette in the final match of the fourth round for the women.

Linette (+1400) is one of two unseeded players to reach the quarterfinals. She joins Donna Vekic (+1200), the 26-year-old tour veteran who will attempt to take out Sabalenka. Linette will face 30th-seeded Karolina Pliskova (+1000).

–Field Level Media

Novak Djokovic slammed his way into the Australian Open quarterfinals for the 13th time with a light workout against Alex de Minaur.

The 23-year-old Australian never forced a break point, but Djokovic broke serve six times to continue his march toward a 10th singles title in the Aussie Open.

Djokovic’s left hamstring was not a topic of discussion for the first time in Melbourne, where the Serbian advanced to a Grand Slam quarterfinal for the 54th time.

“I didn’t feel anything today,” he said.

Djokovic labored in a 7-6 (7), 6-3, 6-4 victory over Bulgarian Grigor Dimitrov on Saturday and needed every point to eliminate France’s Enzo Couacaud, 6-1, 6-7 (5), 6-2, 6-0. Djokovic, 35, paused several times to stretch during the takedown of Couacaud in the second round.

Health was a non-factor Monday.

“A week ago I didn’t really think about the title, I just thought about being in a good enough condition to play the next match,” Djokovic said. “Tonight, the way I played, the way I felt, gives me reason now to believe that I can go all the way.”

Djokovic takes on No. 5 seed Andrey Rublev (Russia) on Wednesday. Rublev battled back from down 5-2 in the fifth set to stun No. 9 Holger Rune 6-3, 3-6, 6-3, 4-6, 7-6 (9) at Rod Laver Arena.

Ben Shelton, the 20-year-old American, is in his first Grand Slam quarterfinal, outlasting countryman J.J. Wolf in a 3 3/4-hour seesaw match. The southpaw Shelton won 6-7 (5), 6-2, 6-7 (4), 7-6 (4), 6-2 and moved into the quarterfinals.

Shelton plays for his father, Bryan Shelton, at the University of Florida. Bryan Shelton is the head coach of the Gators’ team and once ranked as high as No. 55 in singles on the ATP Tour.

“It’s been a pretty special week for me,” said Ben Shelton, who is overseas for the first time and said he’s never used a passport.

“I got on the plane with no expectations. I know that it’s very hard to adjust to Australia from the United States just with the jetlag, time change and everything. It being my first time, never being out of the United States, I knew it would be a struggle.”

Another unseeded American, 35th-ranked Tommy Paul, awaits on Wednesday. Paul eliminated No. 24 seed Roberto Bautista Agut of Spain 6-2, 4-6, 6-2, 7-5 on Monday.

And 25 years after his father won the Australian Open, Sebastian Korda won his match on Sunday to give the U.S. three men in the quarterfinals at Melbourne for the first time since Andre Agassi, Pete Sampras and Chris Woodruff pulled off the feat in 2000.

–Field Level Media