PTC Therapeutics, Inc. (NASDAQ:PTCT) demonstrates strong capital efficiency with a ROIC of 31.66% and a WACC of 9.69%, resulting in a ROIC to WACC ratio of 3.27.
Amicus Therapeutics, Inc. (FOLD) leads the peer group with a ROIC of 55.32% and a WACC of 7.39%, achieving a ROIC to WACC ratio of 7.49.
Ultragenyx Pharmaceutical Inc. (RARE) and Agios Pharmaceuticals, Inc. (AGIO) show negative ROIC to WACC ratios, indicating inefficiency in capital utilization.

PTC Therapeutics, Inc. (NASDAQ:PTCT) is a biopharmaceutical company that focuses on the discovery, development, and commercialization of clinically differentiated medicines. The company primarily targets rare genetic disorders, aiming to provide innovative treatments for patients with unmet medical needs. In the competitive landscape, PTC Therapeutics stands alongside companies like Ultragenyx Pharmaceutical Inc., Agios Pharmaceuticals, Inc., Amicus Therapeutics, Inc., and Blueprint Medicines Corporation.
In evaluating PTC Therapeutics’ financial performance, the Return on Invested Capital (ROIC) and Weighted Average Cost of Capital (WACC) are crucial metrics. PTCT boasts a ROIC of 31.66% and a WACC of 9.69%, resulting in a ROIC to WACC ratio of 3.27. This indicates that PTC Therapeutics is effectively using its capital to generate returns, surpassing its cost of capital significantly.
When comparing PTCT to its peers, Ultragenyx Pharmaceutical Inc. (RARE) shows a negative ROIC of -50.05% against a WACC of 7.01%, leading to a ROIC to WACC ratio of -7.14. This suggests that Ultragenyx is not efficiently using its capital, as its returns are far below its cost of capital. Similarly, Agios Pharmaceuticals, Inc. (AGIO) has a ROIC of -27.16% and a WACC of 7.33%, resulting in a ROIC to WACC ratio of -3.71, indicating inefficiency in capital utilization.
Amicus Therapeutics, Inc. (FOLD) stands out with a ROIC of 55.32% and a WACC of 7.39%, achieving a ROIC to WACC ratio of 7.49. This highlights Amicus Therapeutics as the leader in capital efficiency among its peers, as it generates substantial returns on its invested capital relative to its cost. Blueprint Medicines Corporation (BPMC), on the other hand, has a ROIC of -17.59% and a WACC of 8.33%, resulting in a ROIC to WACC ratio of -2.11, indicating less efficient capital use.
In summary, while PTC Therapeutics demonstrates strong capital efficiency with a positive ROIC to WACC ratio, Amicus Therapeutics leads the peer group with the highest ratio, showcasing its superior ability to generate returns on invested capital.