The Seattle Seahawks ruled out leading rusher Kenneth Walker III from Sunday’s game against the Arizona Cardinals due to a calf injury.

Walker was listed as questionable on Friday’s injury report before being downgraded to out on Saturday.

Walker has rushed for 542 yards and seven touchdowns this season, his third with Seattle. He rushed for 1,050 yards and nine touchdowns as a rookie and 905 yards and eight scores last season.

Zach Charbonnet will start in place of Walker. The second-year pro has 266 rushing yards and five touchdowns this season.

Charbonnet started twice earlier this season while Walker was sidelined by an oblique injury. He had career bests of 91 yards and two touchdowns on the ground during a 24-3 rout of the visiting Miami Dolphins on Sept. 22.

Kenny McIntosh, who has four carries for 16 yards, will be the backup running back against Arizona. Seattle elevated George Holani from the practice squad to be the No. 3 running back. Holani is a rookie from Boise State.

Seattle also elevated punter Ty Zentner from the practice squad on Saturday. Regular punter Michael Dickson (back) was unable to punt in the fourth quarter of last week’s victory over the New York Jets and is listed as questionable.

Also, cornerback Tre Brown (hamstring) was added to the injury report as doubtful.

The contest is a big one for the NFC West as Seattle (7-5) leads the division by one game over Arizona (6-6) and the Los Angeles Rams (6-6).

–Field Level Media