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From marmots to mole-rats to marmosets — studying many genes in many animals is key to understanding how humans can live longer

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Is there a genetic switch that can help reverse the aging process?
Dimitri Otis / Getty Images

Amanda Kowalczyk, University of Pittsburgh

Much of longevity and aging research focuses on studying extremely long-lived species, including bats, naked mole-rats and bowhead whales, to find genetic changes that contribute to long life.

However, such work has yielded highly species-specific genetic changes that are not generalizable to other species, including humans. As a graduate student, I have studied growing evidence, including recent work from my advisers’ labs (Maria Chikina and Nathan Clark), that supports the hypothesis that lifespan is a complex and highly context-dependent trait that calls for a shift in how biologists think about aging.

Old age: The human problem

Aging is the process by which the likelihood of death increases the longer an organism is alive. In mammals, aging is hallmarked by several molecular changes, including the breakdown of DNA, a shortage of stem cells and malfunctioning proteins.

Numerous theories that exist to explain why aging happens fall into two categories. “Wear-and-tear” theories postulate that essential processes simply wear out over time. On the other hand, “programmed death” theories assert that specific genes or processes are designed to drive aging.

Traditional definitions and aging theories are human-centric, and when we examine aging from a cross-species perspective, it becomes clear that human aging is unique. In fact, among animals there is no typical way to age.

Humans show low mortality rates until a sharp spike in mortality at very old age, around 80 years. Most mammals have relatively less increase in mortality with age and more consistent mortality through their lifespans. Some mammals, such as the tundra vole and the yellow-bellied marmot, show virtually no increase in mortality with age. In other words, older individuals are equally as likely to die as younger individuals, possibly because aging does not impact survival.

Current aging theories fail to explain the full complexity of aging across all mammals, let alone the tree of life. Such diversity not only highlights the complexity of aging and longevity but also makes it difficult to apply knowledge gained about one species to increase lifespan in another.

A bowhead whale and a surfer in Vrangel Bay. Bowhead whales, also known as Greenland right whales, can weigh from 75 to 100 tonnes.
Yuri Smityuk\TASS via Getty Images

An overabundance of ‘longevity genes’

Studies of exceptionally long-lived species have produced a plethora of so-called longevity genes. One such gene, called the insulin-like growth factor 1, or IGF1, receptor gene, promotes cell growth. IGF1 was originally associated with long life in bats and also increases lifespan in worms and mice. However, IGF1 may have the opposite effect in humans, because too much IGF1 may increase age-related illnesses like diabetes and cancer.

 

Another potential longevity gene called the ERCC1 gene produces a protein that helps repair DNA. The bowhead whale, the longest-lived mammal at 211 years, has a mutation in the ERCC1 gene that may contribute to the species’ exceptionally long lifespan, but the mutation is not shared by other long-lived species. Elephants have 19 copies of the TP53 gene, an essential cancer prevention gene, but adding even one extra TP53 gene to mice accelerates aging because stem cells are slower to regenerate.

Longevity genes can be inconsistent even within a single species. Studies that hunt for genetic changes common in long-lived humans, and absent from humans who lived shorter lives, have not delivered a master longevity gene. The genes detected are largely inconsistent across studies and rely heavily on the subpopulation of humans sampled and the precise definition of “exceptionally long-lived.”

So how do we find longevity genes?

My recent work underscores the argument that aging researchers should not be looking for individual longevity genes. Instead biologists should be seeking many genes with similar functions working together to control longevity. Further, an effective search should not just focus on a single species, but many, to avoid species-specific elements.

As part of a research study, I used genomes from 61 mammals to detect genes that evolved in tandem with the evolution of extreme lifespan, thereby uncovering longevity-related changes universal across all mammals. At the gene level, I found few longevity genes, which makes sense in light of previous work. There is probably no single gene in all mammals that regulates lifespan.

When I looked at the big picture, however, and considered groups of genes working together to perform a similar function, I found a strong association between longevity and pathways related to controlling cancer. Examples of such groups of genes are those involved in regulating the cell cycle and programmed cell death, and pathways for immune function and DNA repair. All of these functions have been previously implicated in lifespan regulation in a wide variety of studies.

My work highlights the importance of a new perspective on aging and longevity.

Species-specific and human genome-wide association studies have limitations that may be enriched by a broader analyses, both in terms of the genomic elements studied and the species considered. Rather than searching for a single gene in a single species that drives increased lifespan, broadening the search to many genes across many species can bring new insights.

One modified genome-wide approach using information about functional relationships among genes found an association between the human IGF1 pathway and longevity scattered over nine genes, a key example of broadening the search for the genetics of lifespan beyond single genes.

Similarly, comparative studies like mine that interrogate genetic similarities and differences among long-lived species have repeatedly demonstrated the power to detect longevity-related genetic changes spread over many genes and shared across many species.

While there may not be a proverbial genetic “Fountain of Youth” — one single genetic change that magically allows us all to live longer — scientists like me are continually improving our strategies to study longevity so we can someday all have longer, healthier lives.The Conversation

Amanda Kowalczyk, Ph.D. Candidate in Computational and Systems Biology, University of Pittsburgh

This article is republished from The Conversation under a Creative Commons license.

Former Angels Executive Eric Kay Charged With Distributing Drugs in Tyler Skaggs Case

Los Angeles Angels former executive Eric Kay has  been charged by federal authorities in Texas with distributing fentanyl which led to the overdoes death of Angels pitcher Tyler Skaggs. An affidavit of the criminal complaint filed against Kay in U.S. District Court in Fort Worth said the longtime member of the Angels’ media relations department and Skaggs had a “history of narcotic transactions” and that Kay would “distribute these pills to [Skaggs] and others in their place of employment and while they were working.”

Kay was arrested and made his first court appearance Friday at the Mahon Federal Courthouse in Fort Worth. They also unsealed the complaint against him that had been filed last week. “Tyler Skaggs’ death coming as it did in the midst of an ascendant baseball career, should be a wake-up call,” Erin Nealy Cox, the U.S. attorney for the Northern District of Texas, said during a news conference Friday. “It should prove to his many, many fans that no one is immune from the deadly addictive nature of these drugs, whether sold as a powder or hidden inside an innocuous-looking tablet. Nealy Cox said the federal investigation remains “open and active.”

Skaggs, 27, died in his Southlake, Texas, hotel room  on July 1, 2019, hours before the Angels were to play the Texas Rangers. He was discovered on his bed, fully clothed, with no signs of trauma. A toxicology report by the Tarrant County medical examiner found the opioids fentanyl and oxycodone in his system. The medical examiner listed the cause of death as “alcohol, fentanyl and oxycodone intoxication with terminal aspiration of gastric contents,” meaning he choked on his vomit.

“It was later determined that but for the fentanyl in [Skaggs’] system, [he] would not have died,” the affidavit by Drug Enforcement Administration special agent Geoffrey Lindenberg said in a statement Friday on behalf of the Skaggs family, attorney Rusty Hardin said they were “deeply heartbroken to learn that Tyler would be alive today if not for a pill containing fentanyl” allegedly provided by Kay.

“We are relieved that no one else who was supplied drugs by this Angels executive met the same fate as Tyler,” the statement said. “While nothing will replace the loss of Tyler, we are very grateful to federal prosecutors for their diligent and ongoing work.” Inside Skaggs’ hotel room, authorities found white powder on the floor and a blue pill marked “M/30.” Both tested positive for fentanyl.

The affidavit said the blue pill had the appearance of a “legitimate prescription 30 milligram oxycodone tablet,” but that the presence of fentanyl “indicates that the pill was counterfeit.”

Investigators, including a Drug Enforcement Administration agent, learned that several unnamed individuals were aware that Kay provided pills – the oxycodone pills they referred to as “blues” and “blue boys” – to Skaggs, according to the affidavit.

Kay distributed the drugs, the affidavit alleged, “beginning in or before 2017.” He worked for the Angels for 24 years before departing in the wake of Skaggs’ death.

“We learned that there was unacceptable behavior inconsistent with our code of conduct, and we took steps to address it,” the Angels said in a statement. “Our investigation also confirmed that no one in management was aware, or informed, of any employee providing opioids to any player, nor that Tyler was using opioids.

In an interview with The Los Angeles Times in June, Skaggs’ widow said she was stunned that drugs were involved in her husband’s death.  “He didn’t exhibit any behaviors of someone who was abusing or addicted to drugs,” Carli Skaggs said.

Kay said in a statement  issued through his attorney in October that he was cooperating with the federal investigation into Skaggs’ death because it was “the right thing to do” and “it’s time for everybody to stand up and take responsibility for their respective roles.”

The attorney, Michael Molfetta of Newport Beach, previously described Skaggs as “an addict who overdosed and I  just know that attempts to blame any one person for another person’s addiction are extremely naive,” Molfetta said last year. “I think any attempts to blame Eric Kay for what happened are shortsighted and misguided. When all the facts come out, I think that what happened is a tragedy. What happened is incredibly sad on many levels. But to say it’s any one person’s fault is not right.”

At least six Angels players, including current pitchers Andrew Heaney and Noé Ramirez and former pitchers Matt Harvey and Trevor Cahill, were questioned by federal agents  last fall as part of the investigation.

The agents hoped the players would shed light on whether the use of opiates was prevalent among their teammates. Agents also asked players if they ever saw others using illegal narcotics on team flights and if they knew how Skaggs acquired the drugs.

In response to Skaggs’ death, MLB and the players union agreed to a new drug-testing policy beginning with the 2020 season. The policy calls for treatment, not suspension, of players who test positive for opioids or other drugs of abuse. It also declassifies marijuana as a drug of abuse.

Under the new policy, players are tested regularly for opioids, fentanyl, cocaine, and synthetic tetrahydrocannabinol (THC). Major leaguers previously were tested for opioids or marijuana only when team or league officials had reasonable cause.

The league and players union also established mandatory educational programs examining the “dangers of opioid pain medications and practical approaches to marijuana.”

 

Skaggs, who attended Santa Monica High, was under contract with the Angels, for $3.7 million in 2019 and would have had one more year of arbitration before becoming a free agent in 2021. He was 7-7 with a 4.29 ERA in 15 starts in 2019 and had a career record of 28-38 with a 4.41 ERA in 96 starts.

 

Image Credit Wikimedia

 

Manny Still Being Manny at 48 Staging Baseball Comeback

Boston Red Sox legend Manny Ramirez is still trying to play baseball. The former Cleveland Indians and Los Angeles Dodgers star last played in 2017  for the Fight Dogs of Japan’s independent Shikou Island League.

When his career ended in 2011, Ramirez joined the then-EDA Rhinos in the Chinese Professional Baseball League. And in just a half of a season, he batted .352 with eight homers and 43 RBI.

Ramirez, a 12-time MLB All-Star, is looking to play in New Zealand for the Auckland Tuatara, according to the team’s chief executive.  Ramirez reportedly reached out to the team about an opportunity to play in the Australian Baseball League for the 2020-21 season.

“This is real. If we can make it work, we’re a safe harbor,” said chief executive Regan Wood. “If he can get in and play, there are all these ABL connotations whether we go across the ditch or not. It’s a real conversation. He’s a pretty laid-back character.”

Ramirez recently told the Taiwan Times that he missed the feeling of completing.  “My goal for 2020 is to find a spot in the [CPBL] I have been itching to get back in the batter’s box and be able to compete again,” Ramirez said to the newspaper. “I also miss being around teammates and team dinners post-game.”

Ramirez was the World Series MVP during the Red Sox’s 2004 championship run. He is currently ranked 15th on Major League Baseball’s all-time home run list with 555.  His 29 postseason home runs are the most in MLB history. He appeared in 12 All-Star Games,  with a streak of 11 consecutive games beginning in 1998 that included every season that he played with the Red Sox.

The charismatic Ramirez is widely known for his out-going personality and competitive nature. He’s loved by his teammates as well as baseball fans all over the world.

Born in the Dominican Republic, Ramirez moved to New York City when he was 13 years old with his parents, and later went on to be a #1 draft pick for the Cleveland Indians in 1991, with the 13th selection overall.  He made his MLB debut on September 2, 1993 and went on to win the Rookie of the Year Award in 1995.

The most controversial part of Ramírez’s career was when he tested  positive for steroids in 2009 and was  suspended 50-games for violating MLB’s drug policy by taking  human chorionic gonadotropin  (hCG), a women’s  fertility drug  that is often taken after  steroids.

In the spring of 2011, Ramirez was informed by MLB of another violation of its drug policy,  and a 100-game suspension.  He chose to retire  on April 8  rather than appeal the suspension.  However, in September 2011, Ramirez wished to be reinstated and agreed in December with the league to a reduced 50-game suspension. Though he played at various points in the Oakland A’s, Texas Rangers, and Chicago Cubs systems, as well as international,  Ramirez did not appear in another Major League game.

Known as a complete hitter who could hit for both power and average, and widely regarded as one of the best right-handed hitters of his generation, I don’t think there’s any reason why Ramírez can’t still play at 48 years old, in New Zealand. Especially since Julio Franco, 49, and Ichiro Suzuki, 45, both played well past their prime in Major League Baseball.

Photo Source: Manny Ramirez  

Elon Musk Gives SpaceX Employees the Day Off After Successful Week of Missions

 

On Friday, August 7 at 1:12 a.m. EDT, 5:12 UTC, SpaceX launched its tenth Starlink mission, which included 57 Starlink satellites and 2 satellites from BlackSky, a Spaceflight customer.

Falcon 9’s first stage previously supported Crew Dragon’s first demonstration mission to the International Space Station, launch of the RADARSAT Constellation Mission, and the fourth and seventh Starlink missions.

Following stage separation, Falcon 9’s first stage landed on the “Of Course I Still Love You” droneship stationed in the Atlantic Ocean.

On Monday, July 20 at 5:00 p.m., SpaceX’s Falcon 9 launched the ANASIS-II mission from Space Launch Complex 40 (SLC-40) at Cape Canaveral Air Force Station in Florida.Falcon 9’s first stage previously launched Crew Dragon to the International Space Station with NASA astronauts Bob Behnken and Doug Hurley on board.      New Source SpaceX

SpaceX says Starlink internet has high   interest  with almost 700,000 interested in service SpaceX’s Starlink internet hopes to solve the rural vs. urban internet divide for better connections  at an estimated cost: $80/mo.

Photo by  SpaceX  on  Unsplash

Pfizer Announces Agreement with Gilead To Manufacture Remdesivir For Treatment Of Covid-19

 

Pfizer Inc. (NYSE: PFE) today announced a multi-year agreement with Gilead Sciences, Inc. to manufacture and supply Gilead’s investigational antiviral remdesivir, as one of multiple external manufacturing organizations supporting efforts to scale up supply of the investigational treatment for COVID-19. Under the terms of the agreement, Pfizer will provide contract manufacturing services at Pfizer’s McPherson, Kansas facility to manufacture and supply remdesivir for Gilead. Source Investor Relations Pfizer

Granted Emergency Use Authorization (EUA) by the FDA for the treatment of COVID-19 VEKLURY ® (remdesivir) is authorized for use under an EUA only for the treatment of patients with suspected or laboratory-confirmed SARS-CoV-2 infection and severe COVID-19. Severe disease is defined as patients with an oxygen saturation (SpO2) ≤94% on room air or requiring supplemental oxygen, mechanical ventilation, and/or extracorporeal membrane oxygenation (ECMO). VEKLURY is authorized for adult or pediatric patients who are admitted to a hospital and for whom use of an IV agent is clinically appropriate. VEKLURY must be administered intravenously. Source: Remdesivir

During his more than 25 years at Pfizer, Albert Bourla, Dvm, Ph.D   has built a diverse and successful career, holding a number of senior global positions across a range of markets and disciplines. Prior to taking the reins as CEO in January 2019, Albert served as the Pfizer’s Chief Operating Officer (COO) beginning in January 2018, responsible for overseeing the Company’s commercial strategy, manufacturing, and global product development functions.

Previously, from February 2016 to December 2017, Albert served as Group President of Pfizer Innovative Health, which comprised the Consumer Healthcare, Inflammation & Immunology, Internal Medicine, Oncology, Rare Disease and Vaccines business groups.

Mark Zuckerberg is Now Worth $100 Billion

 

Mark Zuckerberg Now Worth $100 Billion .Only Jeff Bezos of Amazon and Bill Gates of Microsoft have passed the net worth of 100 billion.

Mark Zuckerberg enrolled at Harvard University in 2002. On February 4, 2004, he launched thefacebook.com and later names it Facebook in 2005,Facebook became a directory where  fellow Harvard students uploaded their personal  information and photos into a template that he had devised. This information publicized  to each individual’s network of friends and  to friends of friend, in what Zuckerberg called the “social graph.” In May 2005 Facebook received its first major investment of venture capital  of $12.7 million.

Zuckerberg turned down a $1 billion buyout offer from Yahoo!, and later in 2007 Facebook Microsoft paid $240 million for a 1.6 percent stake in Facebook. Two years later Digital Sky Technologies purchased a 1.96 percent share for $200 million. After Facebook, Inc. (FB) Nasdaq GS  initial public offering (IPO) in 2012, Zuckerberg’s net worth was estimated at more than $19 billion.

Facebook both ad revenues and subscribers came in ahead of expectations.

Revenues overall rose nearly 11%, to $18.69B; ad revenues rose 10% to $18.32B.

Operating income jumped 29% to $5.96B, with margin of 32%.

And amid a sharply lower effective tax rate (16% vs. 46%), net income nearly doubled, to $5.18B.

Daily active users were 1.79B (up 12%), topping expectations for 1.74B, and monthly active users also rose 12%, to 2.7B. Source:CWEB

Following Massive Explosion, Pentagon Flies Aid to Beirut

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AUG. 6, 2020 |  BY  C. TODD LOPEZ, DOD NEWS

The Pentagon is in the process of shipping supplies to Beirut to provide much-needed assistance in the aftermath of a massive explosion in the Lebanese capital, the assistant to the secretary of defense for public affairs said.

“We … want to express the department’s sympathies in mourning the lives of so many lost in Lebanon on Tuesday. This is a horrific tragedy,” Jonathan Rath Hoffman said during a Pentagon news conference today.

23:38

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Hoffman said Marine Corps Gen. Kenneth F. McKenzie Jr., commander of U.S. Central Command, has talked with the commander of the Lebanese armed forces to inform him that three C-17 aircraft will bring relief supplies to Lebanon.

The first C-17 Globemaster III aircraft has already arrived in Beirut to deliver supplies, a Centcom statement said today. Included in those supplies are 11 pallets of food, water and medical supplies.

U.S. President Donald Trump’s administration will impose sanctions on Hong Kong Chief and TikTok

President Donald Trump has taken aim at China again, signing a pair of executive orders targeting not only TikTok but also widely used WeChat. The action references national security concerns and (starting in 45 days) bars any transactions with the apps’ China-based owners – ByteDance (BDNCE) and Tencent Holdings  (OTCPK:TCEHY)  – by any person or involving any property subject to the jurisdiction of the U.S. While TikTok said it will pursue all remedies available, including American courts, it also faces a Sept. 15 deadline before its services are banned in the U.S.

U.S. President Donald Trump’s administration will impose sanctions on Hong Kong Chief Executive Carrie Lam and other Chinese officials on Friday. for their role in curtailing political freedoms in the territory.

Photo Credit: White House

Five ways to reboot the global food economy to make it healthier for all

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Shutterstock.com

Corinna Hawkes, City, University of London

COVID-19 has shown how damaging ill-health can be for the economy. But it has also shown how measures that benefit health (lockdowns) can be seen as bad economic prosperity. A similar paradox is at the heart of promoting better diets.

Poor diet is the world’s leading cause of ill-health. Malnutrition — from undernutrition to obesity — affects at least one-third of the global population. It’s an issue of inequality, too: diet-related challenges disproportionately affect poorer people, making the economic challenge even greater.

Poor nutrition also costs businesses dearly. A recent report by research institute Chatham House estimates that businesses around the world lose as much as US$38 billion ( £29 billion) a year from undernutrition and obesity among their workforce. Nevertheless, when governments attempt to take unhealthy foods out of the spotlight and place more nutritious foods centre stage, they typically rub up against economic arguments that any regulation will hurt business.

COVID-19 has shown it’s time to change. Obesity, diabetes and other chronic conditions associated with unhealthy diets increase the risk of complications from the virus (a point not lost on UK prime minister Boris Johnson, who had his own battle with the virus).

There are also predictions that the pandemic will lead to a crisis of undernutrition. As discussions about how to renew the global economy — and rethink the economic system — are heating up, food must be part of our thinking.

This five-point plan could do the work of resetting the food economy over the short term, allowing it to both flourish and nourish over the long term.

1. Financing for healthy food

Healthier food costs more. Investment is needed all the way along the food-value chain to make a healthy diet more affordable for the 3 billion people around the world who cannot afford one.

Public spending on agriculture — like subsidies for fertilisers, payments direct to farmers and plant breeding programmes, as well as policies to attract private sector investment — tends to favour crops like maize, palm oil, rice and soybeans.

These crops dominate the unhealthy food industry and leave children in low-income countries undernourished. This investment could be reallocated to diversifying and building supply chains for more nutritious foods like fruits, vegetables, beans and whole grains.

Tractor sprays pesticides on soybean field.
The building blocks of most junk food is heavily subsidised.
Shutterstock

Investment is needed in local food supply chains too, connecting smaller and more sustainable producers of nutritious foods to consumers who need them most. E-commerce initiatives are growing in the wake of COVID-19 in many lower income countries and could be built on.

Food hubs that bring food from producers to commercial customers or direct to consumers are also growing. This would support local food economies in countries rich and poor.

Innovative financing is a vital part of the picture. For example, the Global Alliance for Improved Nutrition, an organisation working to improve the consumption of nutritious foods, has a programme that encourages investment in nutritious food businesses in low- and middle-income countries. These are small- and medium-sized businesses that play an important role in creating jobs and boosting regional economies.

In London, the Good Food Fund is a new £1.8 million business accelerator and venture fund designed to back SMEs and start-ups to produce healthier snacks for kids.

2. Make junk food less attractive

It’s relatively easy to make money by selling cheap snacks to kids and adults alike. Companies compete with each other to tempt consumers everywhere, from Dakar to Dublin. A small amount of regulation would incentivise healthy, rather than unhealthy, competition.

The fact that during lockdown some large corporations have been vying for greater market share for their cookies, pizzas and burgers shows that as long as businesses have the incentive to promote unhealthy products, they will continue to do so.

In Chile, for example, the government introduced tough, comprehensive regulations forcing food manufacturers to clearly label and market their products with how healthy (or unhealthy) they are. This enabled innovators to compete with the junk food industry and appeal to the health conscious. Similarly, taxes on sugary drinks in many countries has incentivised the industry to produce healthier products.

3. Profit with purpose

Another way to get food businesses to sell healthier products is through corporate governance mechanisms. Instead of focusing on shareholder profits, food companies could establish diet-related health as a core purpose.

Here, there is ample scope to join the growing ranks of “B corporations”. These are businesses that emphasise “social and environmental performance” alongside shareholder value. This could easily include health as a metric for food businesses.

4. Redefining success

A new package of healthy metrics is needed to define what success looks like for food businesses large and small. The Access to Nutrition Index, for instance, scores global food companies on how well they are addressing obesity and diet-related disease. In the UK, the Food Foundation has proposed metrics for investors to assess how well businesses are managing the risks and opportunities in the transition towards healthier food.

5. Public sector leading the way

Scores of cities around the world already have public procurement standards that ensure the millions of meals they serve daily in schools, nurseries, hospitals and prisons are healthy, while also providing stable markets to support vulnerable parts of the economy.

In “homegrown school feeding” and “farm-to-school” programmes, for example, public budgets are used to purchase healthy food from smaller, family, farmers while ensuring kids are well fed. Evidence from Nepal and the United States shows that if designed well, these programmes work.

Implementing this five-point plan will have its challenges. But every element has been tried and tested already. It’s all doable. The task now is to implement them as a package to ensure the different elements are in place to repurpose the food economy — and indeed reform the global economy — for better, healthier eating.

The coronavirus has highlighted that the public is eager to see courageous leadership. Now is the time to step up and ensure we have an economy that is both nourishing and flourishing.The Conversation

Corinna Hawkes, Professor of Food Policy, City, University of London

This article is republished from The Conversation under a Creative Commons license.

Google Still Dominates

Alphabet, Inc. ( GOOG) has a price upside of 124% and its stock due to increased internet usage by 18%. Covid-19 and staying at home or search usage in Google is up. People are online more than ever nowadays. Google relies heavily on advertising and advertising is what is growing their Market. We look at strong Revenue growth of about 24% moving forward annually due to emerging AV technologies  rising cloud adoption technology which are  non-ad segments.

Google and Facebook (FB) have   about  70% of market share for advertising. 70% of Googles  revenue is generated through Search and YouTube Ads. Google’s revenue has grown a magnificent  average annual growth rate of 21.05% for  the past 10 years. Mobile usage   is  increasing 7% on average over the past 5 years.

Search is strong at 91.98% of global market share. In 2019, search advertising spending stood at nearly 106.5 billion U.S. dollars worldwide. This amount is projected to grow to about 132 billion U.S. dollars by 2022. Display advertising, which reached 161 billion U.S. dollars, accounted for the largest ad spend share in 2019. Source Statistica

Google is the worldwide search market leader with a constant global market share around 90 percent. In the United States, Google is also ranked first among unique visitors and core searches. Recent online search figures indicate heavy online search usage in European countries. Source Statistica

Google faces the threat of Amazon (AMZN)  for the e-commerce. It recently announced Google Shopping will be free.

Alphabet Issues Sustainability Bonds to Support Environmental and Social Initiatives.

Today, as part of a $10 billion debt offering, we have issued $5.75 billion in sustainability bonds, the largest sustainability or green bond by any company in history. Although a number of companies have issued green bonds (directed solely to environmental uses), sustainability bonds differ in that their proceeds support investment in both environmental and social initiatives. Such bonds are an emerging asset class and we hope this transaction will help develop this new market. We’re encouraged that there was such strong demand for these bonds from investors – they were significantly oversubscribed.

The proceeds from these sustainability bonds will fund ongoing and new projects that are environmentally or socially responsible and enable investors to join us in tackling critical issues. We believe that these investments benefit our communities, employees, and stakeholders, and are an important part of fulfilling Google’s mission and goal of creating value over the long term. Source: Google

CWEB Analyst see Google stock as a safe bet for long term growth and a great addition to one’s portfolio and upward of $2300 by 2021

Photo by  Morning Brew  on  Unsplash

Google Invests $450 million to acquire 6.6% ownership of ADT